Yes. Consanguineous marriage can increase the likelihood of certain genetic disorders because relatives are more likely to share the same genetic variants. If both parents carry a disease-causing variant in the same gene, the chance that their child will be affected increases.

Autosomal recessive conditions may be seen more frequently in consanguineous families. Examples include:

• Cystic fibrosis
• Phenylketonuria
• Sickle cell disease

The background risk of congenital disorders in the general population is approximately 2–3%; in consanguineous couples it may rise to around 4–6%. This does not mean that every consanguineous couple will have a child with a genetic disorder.

What Should You Do?

A genetic risk assessment is advisable before marriage or when planning a pregnancy. Carrier screening and genetic counseling can help clarify individual risks.

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